Arsenal manager Mikel Arteta has detailed the club's injury issues, with Thomas Partey out for "weeks" and Mohamed Elneny set to be absent for "months".
The Gunners have enjoyed a perfect start to the Premier League campaign with five wins from five but face a stern test at Old Trafford on Sunday against Manchester United, who have bounced back from a slow start to register three consecutive wins.
Midfield injuries have become an issue for Arteta, though, forced to make changes in back-to-back matches in the middle of the park with Albert Sambi Lokonga deputising as Granit Xhaka's partner in midweek.
Arsenal have further problems, too, with Oleksandr Zinchenko missing the last two games and yet to train with the team, while Aaron Ramsdale and Martin Odegaard will be assessed on Saturday.
"Ramsdale and Odegaard have been assessed and we will see more tomorrow. Hopefully they'll be available to train with the team," Arteta said in Friday's press conference.
"Alex [Zinchenko] missed two games and has not been able to train with team yet. For Mo [Elneny], we are talking months.
"With Thomas [Partey], we are hopefully talking weeks and even shorter than that. We have tried to manage him. A lot has happened since he's joined.
"We are trying the possible way to find reasons for that. Unfortunately, his body and mind are too difficult to try to put finger on to identify one factor. Attitude is there. He's really disappointed and wants to get back."
Arsenal attempted to make a late move to sign Douglas Luiz from Aston Villa but were unable to thrash out a deadline day deal, with Arteta admitting he may look towards the academy for players to make the jump.
"We had to react. We tried, but we have to bring in the right player for the team and for the club but didn't manage to do that," he added.
"It's the team we have. For me, it's the best squad and team I have available. There is nothing else we can do. We have an academy as well that we have to use, and we will try to do that the best possible way."
PSG close in on Ligue 1 title with 4-1 win at Lorient
Paris Saint-Germain closed in on a record-extending 12th Ligue 1 title as Ousmane Dembele and Kylian Mbappe each scored twice in a 4-1 away victory against second-from-bottom Lorient on Wednesday.
Luis Enrique's side will seal the title later on Wednesday if second-placed Monaco fail to beat Lille at home.
PSG are on 69 points with four games left with Monaco trailing by 14 points.
PSG were without the in-form Bradley Barcola, Marquinhos, Achraf Hakimi, Vitinha and Warren Zaire-Emery who were rested a week before the team's Champions League semi-final first leg against Borussia Dortmund.
The capital side went ahead on 19 minutes as Dembele beat two defenders before slotting the ball past Yvon Mvogo from just inside the box.
Three minutes later, Mbappe connected with a Nuno Mendes cross to double the advantage.
Dembele then put the result beyond doubt on the hour mark when he tapped in from Mbappe's cross.
Mohamed Bamba reduced the arrears in the 73rd minute, but it was too little, too late for a team with 26 points from 30 games.
Mbappe added another one in the last minute with a right-footed effort to take his season tally in the top flight to 26.
Premier League title race gets Man City's blood pumping - Guardiola
Pep Guardiola relishes the decisiveness of the Premier League run-in, as Manchester City prepare for another huge game in the title race.
The Citizens breezed past Luton Town 5-1 at the Etihad Stadium in their last outing in the competition, but were not in Premier League action at the weekend.
While they booked a place in the FA Cup final with a 1-0 win against Chelsea on Saturday, Arsenal went back to the summit by recording wins over Wolves and the Blues before Liverpool also leapfrogged Guardiola’s team with a 3-1 victory at Fulham on Sunday.
City, who will be without the injured Erling Haaland, face Brighton on Thursday, in what is one of their two games in hand on the Gunners.
Asked how he feels going into the final few games of the season with so much on the line, Guardiola said: “Every game is adrenalin. Every game is important. But yes it’s decisive. Every mistake or every step back makes it more difficult. It is what it is.
“We have been here in the last years fortunately many times so that’s why we know what we are playing for.”
Guardiola was also questioned about the criticism levelled at match officials after Nottingham Forest’s strongly worded statement following their 2-0 defeat at Everton on Sunday.
"Absolutely disagree. In every league in the world, this kind of thing will happen more and more, but of course, I never had doubts about that,” said Guardiola.
"They make a mistake, they feel bad. It's normal. When they do the job, they want to do it well. The game is so difficult, it is fast and quick, decisions have to be made in one instant. It's not easy.”
Grant McCann hails ‘outstanding’ response as Doncaster close on play-off spot
Grant McCann was a proud man after Doncaster won 4-1 at Colchester to register a 10th straight victory and move into the play-off places.
Colchester took a ninth-minute lead through Jayden Fevrier, who converted Tom Hopper’s cross at the far post, but remain in relegation danger after Rovers’ emphatic comeback.
Luke Molyneux equalised after collecting Jamie Sterry’s short free-kick and scoring with a low 25-yard shot and Doncaster took a 22nd-minute lead through Harrison Biggins, who netted from close range from Molyneux’s delivery.
Tom Anderson netted a third in the 76th minute at the near post from Hakeeb Adelakun’s pass, and Joe Ironside sealed victory when he converted after Sam Hornby had tipped James Maxwell’s shot onto a post.
A point on the final day against Gillingham will seal a play-off spot regardless of results elsewhere and McCann said: “I’m really proud.
“Obviously conceding early wasn’t ideal for us but the response was outstanding.
“We scored two very good goals, the first one from Mols (Molyneux) and the second one was another very good goal and something we knew could help us in the game, Biggo’s (Biggins) runs from the centre circle in between the posts after good play by Mols.
“In the first half, we were a little bit edgy and it was a little bit even Steven in the game.
“But in the second half, we were really comfortable and scored another couple of really good goals.
“We always play for more goals; we never sit tight and take what we’ve got – that’s just the way we like to go about things.
“We came up against a team that’s obviously down the wrong end of the table and we knew it was going to be tough.”
Fevrier had Colchester on track to secure survival but they go into Saturday’s final game just three points above the drop zone, with their goal difference superior by four over Sutton.
Colchester boss Danny Cowley said: “It was a tough night for us.
“We have the ability to self-harm, to self-destruct, in a game where we let four terrible goals in.
“For 75 minutes, it was 2-1 and they’ve had three shots at goal, two from 30 yards, and somehow they’re winning the game.
“We were 2-1 down at half-time where we felt we shouldn’t have been, as we’d done a lot right.
“We were in total ascendency and they don’t even want to score any more goals, they want to hang onto what they’ve got and we gift them another two goals.
“I’ve just looked back at the goals and they’re very hard to defend.
“We actually played well box to box but you can’t say you’ve played well when we’ve conceded the goals that we have.
“It’s a damaging night and I’m really angry. We just did the basics so poorly.”
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