Quarterback Brock Purdy threw four touchdown passes as San Francisco 49ers stayed undefeated with a 42-10 win over the Dallas Cowboys.

Purdy threw all but one of his touchdown passes to tight end George Kittle while Jordan Mason, Christian McCaffrey and Kyle Juszczyk all got over the line for a touchdown.

Dallas quarterback Dak Prescott was sacked three times and threw for three interceptions as the Cowboys suffered their biggest defeat since 2013 and their second of the season.

The Kansas City Chiefs added more misery to the Minnesota Vikings tough start to the season, but it was not without a scare as star tight end Travis Kelce went down with an ankle injury in the second quarter.

The Chiefs won 27-20 with Patrick Mahomes throwing for 281 yards with two touchdowns.

Kelce reportedly went for scans on his right foot but returned in the third quarter, scoring a touchdown to put the game out of the Vikings reach and securing the Chiefs fourth win of the season.

Quarterback Jalen Hurts put on a masterclass for the Philadelphia Eagles as they claimed a 23-14 victory at the Los Angeles Rams.

Hurts threw for 303 yards, including one touchdown pass and rushed for 72 yards, scoring a touchdown of his own.

Rams quarterback Matthew Stafford threw for two touchdowns for 222 yards but the Hurts touchdown and a brave defensive performance in the second half kept Philadelphia’s perfect start alive.

The Cincinnati Bengals secured an away win with the help of Joe Burrows who threw for three touchdown passes and 317 yards to give them a 34-20 win against the Arizona Cardinals.

Ja’Marr Chase scored three touchdowns off Burrows’ arm and set a single-game franchise record for the Bengals with 15 receptions, lifting the Bengals to a 2-3 record.

The Miami Dolphins beat the New York Giants at home 31-16 with rookie running back De’Von Achane scoring a 76-yard rushing touchdown and amounting 151 rushing yards.

The win took Miami to the top of the AFC East with a 4-1 record while the Giants suffered their fourth loss.

Elsewhere, the New York Jets took care of the Denver Broncos 31-21, while the Atlanta Falcons pipped the Houston Texas 21-19 and the Pittsburgh Steelers took down the Baltimore Ravens.

The Indianapolis Colts beat the Tennessee Titans, while the New England Patriots were held scoreless in their 34-0 loss to the New Orleans Saints and the Detroit Lions handed the Carolina Panthers their fifth loss of the year, winning 42-24.

Indianapolis Colts rookie quarterback Anthony Richardson injured his right throwing shoulder in his team's 23-16 win over the Tennessee Titans on Sunday.

Richardson was hurt with just over 4 1/2 minutes to go in the second quarter when he was tackled by two Titans on a 4-yard run. He took a hit to the left shoulder but appeared to land awkwardly on the right one.

Immediately upon being tackled he began rubbing his right shoulder and stayed on the ground while the trainers quickly came out to tend to him.

He stayed down for several minutes before making his way slowly to the injury tent. After being evaluated on the Colts sideline, he walked to the locker room with his right arm hanging down to the side as he tried to keep it immobilised.

The team officially ruled him out early in the third quarter.

X-Rays on the shoulder were reportedly negative and he is expected to get an MRI.

Gardner Minshew replaced Richardson and helped lead Indianapolis to a win - the second time this season he's done that.

In the Colts' 31-20 victory over the Houston Texans in Week 2 on September 17, Richardson suffered a concussion when he took a hard hit to the head at the end of a 15-yard touchdown run. Minshew came in and threw for 171 yards and a touchdown.

He was unable to clear the NFL's concussion protocol and missed Indianapolis' win over the Baltimore Ravens in Week 3 before returning for last Sunday's overtime loss to the Los Angeles Rams - the first game of his young career he was able to complete.

Through five weeks of the 2023 NFL season, the dual-threat quarterback has shown glimpses as to why the Colts selected him with the fourth pick in this year's draft, but he's been a bit injury-prone.

In addition to exiting in the wins over the Texans and Titans, Richardson also suffered a knee bruise on a hard hit near the goal line in the final minutes of a 31-21 season-opening loss to the Jacksonville Jaguars. Colts coach Shane Steichen said he could have returned, however, and he was taken out as a precaution.

Prior to exiting Sunday, Richardson completed 9-of-12 passes for 98 yards. He also ran twice for 5 yards and was sacked once.

On the season, he has passed for 577 yards with three touchdowns and one interception and has rushed for 136 yards with four TDs on the ground.

Buffalo Bills head coach Sean McDermott would welcome a return trip to London despite admitting his side seemed sluggish in their 25-20 loss to the Jacksonville Jaguars at Tottenham Hotspur Stadium.

Buffalo, led by quarterback Josh Allen and seeking their fourth straight victory, entered Sunday afternoon’s contest on a high after beating the Miami Dolphins but found themselves up against an 11-0 deficit after the first quarter.

Though the ‘host’ Bills, who enjoyed the majority support of a raucous 61,273-strong crowd, twice found themselves a touchdown away from staging a fourth-quarter comeback it was the Jags – coming off last weekend’s 23-7 victory over the Atlanta Falcons at Wembley and perhaps better-adjusted to the time zone – who ultimately held on.

Asked if Buffalo, who only arrived in London on Friday, might have been affected by the travel, McDermott said: “We’ll see if, whatever comes up down the road in terms of us coming back here, but we need to evaluate everything because I didn’t feel like our energy was good enough early in the game.

“They had better energy than we did. We’re going to fly back tonight, watch the film on the way home and learn from this and we’ve got to get ourselves back where we need to be fundamentally. It’s just talking about throwing and catching, tackling, right?

“Most of the things that are at the forefront of some of the reasons why we got the result we did today.

“We would absolutely [come back]. We enjoyed just the opportunity to be over here. It’s an honour to be selected to play here and we’re certainly appreciative of our hosts in London.”

While Buffalo had not played in the UK since 2015, Jacksonville have contested at least one match in the British capital every year since 2013 save 2020, when the coronavirus pandemic prevented international matches.

With Sunday’s victory, the Florida outfit became the first team to win NFL international matches in back-to-back weeks, with some speculating they were given a boost both from their familiarity with the UK grounds and, against Buffalo, were the better-adjusted opponent due to remaining in London between contests.

The Jags certainly looked the sprightlier side in the first quarter and Trevor Lawrence the more effective quarterback, Zay Jones completing the first touchdown and Travis Etienne, who would later make two TDs of his own, adding the two-point conversion.

Buffalo, who lost key linebacker Matt Milano to a knee injury in the first quarter, rallied late in the second to make it 11-7 at the halfway point and a scoreless third quarter ensured it was all to play for in the final 15 minutes.

A game largely dominated by defence broke open, both sides adding two touchdowns apiece – the Jags’ from Etienne, while Allen and Gabe Davis added to Buffalo’s score.

Bills wide receiver Stefon Diggs, who collected from Allen for Buffalo’s second-quarter, 15-yard touchdown, refused to blame the cross-continental trip for the result.

He said: “It’s easy to say that after the game. If we’d won would we be saying yeah, we were tired, we were this, we were that.

“It’s easy to use that as an excuse. I’m not a big excuse guy so I won’t say it, but you’re going to have to ask the other guys.

“Tired or not, you’re going to have to get up to play a football game. You get up to do this thing that you love and play this game because it’s a blessing.

“I will never use the excuse of, you can obviously look at the data or whatever, but I feel like we can play better. We will be better.”

The Jacksonville Jaguars became the first team in NFL history to win an international game in back-to-back weeks with a 25-20 victory over the Buffalo Bills at Tottenham Hotspur Stadium.

Many expected in-form quarterback Josh Allen and his hosting Bills to have the upper hand in London, but the visitors were the superior side by almost every measure in the first quarter, where a costly Buffalo penalty led to the Jags’ first touchdown.

And though AFC East leaders Buffalo, looking for a fourth straight win, finally broke through and narrowed the deficit to 11-7 by the halfway point, a scoreless third quarter and a Travis Etienne touchdown extended the Jags’ advantage to double-digits early in the fourth quarter.

Two touchdowns per side in the final 15 minutes kept things interesting as Buffalo twice came within five points of drawing level, but the visitors, who last weekend beat the Atlanta Falcons at Wembley, ultimately did enough to stave off a Buffalo comeback.

The stands – including Formula One driver Daniel Ricciardo – skewed overwhelmingly in favour of Buffalo, but it was the visitors who first sparked to life through QB Trevor Lawrence’s sharp 30-yard pass to wide receiver Christian Kirk.

Jacksonville soon took full advantage after Buffalo’s Ed Oliver was punished with a five-yard penalty and Lawrence fired into the endzone, where a leaping Zay Jones completed the six-yard touchdown, Etienne successfully converting for two more.

Brandon McManus’ 44-yard field goal gave his side an 11-0 lead before the second quarter, where Buffalo pressed on in search of a solution to a Jags defence that, five minutes into the period, had held the hosts to just 35 yards on offence to their 167.

Buffalo finally broke through just before half-time, closing that gap with a 12-play, 86-yard drive ending in Stefon Diggs’ classy 15-yard touchdown reception to collect the pass from his QB with Tyler Bass booting the extra point through the uprights.

That drive alone was 32 yards longer than their first four combined and launched the hosts squarely back into the contest.

A promising third-quarter drive began with a promising 48-yard pass cleverly claimed by Diggs, but the hosts ultimately failed to capitalise on the gained ground.

Buffalo were down to the final 15 minutes after the scoreless third quarter and found themselves frustrated early in the fourth by a brilliant interception by Jags cornerback Darious Williams on Allen’s ball intended for Diggs.

Jacksonville extended their lead to double digits through Etienne, who crossed over from six yards, McManus good for the extra point.

With just over four minutes remaining, the Bills saw a touchdown nullified by a penalty but made good on the second attempt when Allen found Davis for the 19-yard touchdown to make it 18-13, Buffalo failing to convert the extras.

The final few minutes of an afternoon dominated by defence suddenly saw an offensive surge as Etienne crossed for another TD, McManus adding another extra point, but Jacksonville barely had time to celebrate before Allen had crossed into the endzone and Bass’ conversion clawed Buffalo back within five.

The frantic, entertaining close was at least enough to stir the Buffalo faithful, who came just short of seeing their side brilliantly bounce back.

Former All-Pro running back Jonathan Taylor and the Indianapolis Colts have agreed to a three-year, $42million contract extension, multiple media outlets reported Saturday. The deal reportedly includes $26.5million in guarantees.

The extension ends a lengthy and sometimes bitter contract dispute between Taylor and the team that drafted him in 2020.

Taylor, 24, was activated from the physically unable to perform list earlier this week and will have a chance to make his season debut Sunday against the Tennessee Titans.

While recovering from ankle surgery, Taylor missed offseason activities and training camp before being placed on the PUP list.

In his first public comments since June, Taylor told reporters Thursday that he was eager to return to the field.

“If somebody wasn’t committed, they wouldn’t be here. Right now, I’m here and my No. 1 goal is really to attack this first practice," Taylor said. "It’s been over 290 days, I believe. When you’re not doing what you love, you’re going to notice it, so my main goal has been to attack this first day.”

Taylor and Colts owner Jim Irsay engaged in a war of words through the media this summer, with Taylor bemoaning the compensation offered to running backs.

Taylor requested a trade, and the Colts eventually gave him permission to seek a trade partner after Irsay had initially said that Taylor would not be traded.

In the end, Indianapolis (2-2) keeps 2021’s leading rusher and a potent offensive weapon to pair with rookie quarterback Anthony Richardson.

Taylor ran for 1,811 yards and 18 touchdowns in 2021, earning AP All-Pro honours. He had 861 yards and four touchdowns in an injury-shortened season last year.

In 43 career games, Taylor has 4,643 yards from scrimmage and 36 total touchdowns.

Star Indianapolis Colts running back Jonathan Taylor has ended speculation over his future by signing a new three-year deal, according to the NFL.

It has been reported the 24-year-old has agreed a 42 million US dollars deal (£34.3m), of which 26.5m dollars (£21.7m) is guaranteed.

It makes him one of the highest paid running-backs in the league.

Taylor, who could make his first appearance of the season on Sunday after an injury-hit start to the campaign, had been linked with a trade away from the AFC South side during the off-season.

He was drafted by the Colts in the second round of the 2020 NFL draft and set the franchise record for most rushing yards in a season with 1,811 in 2021.

Las Vegas Raiders quarterback Jimmy Garoppolo has cleared concussion protocol and will start Monday night’s game against the Green Bay Packers.

Garoppolo missed Sunday’s 24-17 loss to the Los Angeles Chargers, with rookie Aidan O’Connell making his NFL debut.

Garoppolo was injured in a 23-18 loss to the Pittsburgh Steelers on Sept. 24 but played the entire game and was checked for a concussion afterward.

“There were some hits that game, so it could’ve been a number of different ones,” he said. “But really just after the game, the doctors grabbed me, started going through it, and next thing I know I was in the protocol. So, weird situation, but we got through it.”

The concussion was another setback for the 31-year-old Garoppolo, who has struggled to stay healthy over the past several seasons.

Las Vegas signed Garoppolo to a three-year, $67.5 million contract in March, including $34 million guaranteed, but the 10-year veteran is off to a shaky start with his new team. He has thrown for 709 yards with five touchdowns and six interceptions for the 1-3 Raiders.

“We’re getting there,” Garoppolo said. “Every day, it’s what we’re trying to do. We have to take care of the ball, starting with myself. I think that’s where it all starts. But after that it’s just about making plays. We’ve got playmakers all over the field, just have to get them the rock.”

Chicago Bears have paid tribute to “the ultimate Bear” Dick Butkus following the death of the Hall of Fame middle line-backer at the age of 80.

The Bears led a moment of silence before their win over the Washington Commanders on Thursday.

Born in Chicago, Butkus played his entire football career in the state of Illinois and in his nine years with the Bears, being the third overall choice in the 1965 NFL Draft, he was a five-time first-team All-Pro selection and an eight-time Pro Bowl honouree.

Butkus’ 49 total career takeaways from turnovers rank second in the franchise’s history and he was renowned as one of the fiercest tacklers in the NFL.

A right knee injury forced him to retire at the age of 31 following the 1973 season. Butkus was named in Hall of Fame All-Decade Teams for the 1960s and 1970s. In 1979, Butkus was added to the Pro Football Hall of Fame.

“Dick was the ultimate Bear and one of the greatest players in NFL history,” Bears chairman George H McCaskey said on www.chicagobears.com.

“He was Chicago’s son. He exuded what our great city is about and, not coincidently, what (former head coach) George Halas looked for in a player: toughness, smarts, instincts, passion and leadership.

“He refused to accept anything less than the best from himself, or from his team-mates.

“His contributions to the game he loved will live forever and we are grateful he was able to be at our home opener this year to be celebrated one last time by his many fans.”

NFL commissioner Roger Goodell paid tribute, with a post on X – formerly known as Twitter, reading: “Dick Butkus was a fierce and passionate competitor who helped define the line-backer position as one of the NFL’s all-time greats.

“Dick’s intuition, toughness and athleticism made him the model linebacker whose name will forever be linked to the position and the Chicago Bears.”

Following the Bears’ 40-20 victory on Thursday night – which ended the longest losing streak in the franchise’s history – wide receiver DJ Moore added a heartfelt message to Butkus.

Moore, who finished the game with 230 receiving yards and three touchdowns, posted on social media: “R.I.P Dick Butkus. Was looking over us Tonight”.

The Chicago Bears finally ended the longest losing streak in the franchise’s history with a dominant 40-20 victory over the Washington Commanders.

Dating back to last season, the Bears had lost 14 straight games heading into Thursday night’s clash.

But you would not have known that based on how they started against Washington, scoring three touchdowns and two field goals en route to a 24-point advantage at half-time.

The Commanders were able to offer some challenge in the third quarter, a touchdown and field goal closing the gap to 27-14.

However, Chicago found their offensive groove again in the fourth, clinching the win on a 56-yard completion from quarterback Justin Fields to wide receiver DJ Moore.

Having struggled through his first four games of the season, Fields was back to his brilliant best against Washington.

The 24-year-old threw for four touchdowns – including a hat-trick to Moore – without a turnover.

Washington’s Sam Howell had 388 passing yards and two touchdowns in the losing effort.

Chicago Bears legendary linebacker Dick Butkus, one of the most intimidating players in NFL history, has died. He was 80.

According to a statement released by the team, Butkus’ family confirmed that he died in his sleep overnight at his home in Malibu, California.

Butkus spent his entire nine-year career with his hometown Bears after he was selected third overall in the 1965 draft out of the University of Illinois.

Though his career was shortened due to multiple knee injuries and forced his retirement at age 31, Butkus still racked up 1,020 tackles, 22 interceptions and a franchise-best 27 fumble recoveries in 119 games with the Bears.

Named to the NFL’s All-Decade teams in the 60s and 70s, Butkus garnered a slew of individual awards with six All-NFL selections, two Defensive Player of the Year Awards and eight Pro Bowls.

His hard-hitting style of play earned him several nicknames, including The Maestro of Mayhem, The Enforcer, The Animal and The Robot of Destruction.

He was inducted into the Pro Football Hall of Fame in 1979 in his first year of eligibility and the College Football Hall of Fame in 1978.

His No. 51 jersey was retired by the Bears in 1994.

Butkus only experienced two winning seasons in the NFL and never made the playoffs.

In 1985, the Butkus Award was established to honor the top linebackers at the high school, college and professional levels.

He also had a career after the NFL, playing off his tough-guy image and appearing in commercials for Miller Lite, Prestone, Schick and Visa, as well as film roles in “Any Given Sunday,” “Hang Time” and “The Last Boy Scout.”

Butkus is survived by his wife, Helen and three children.

Star wide receiver Cooper Kupp returned to practise on Wednesday, and could be back on the field as early as Sunday for the Los Angeles Rams' home game against the undefeated Philadelphia Eagles.

Kupp injured his hamstring during training camp in early August, and the team placed him on injured reserve, ruling him out for at least four games.

The Rams announced Wednesday, they've designated Kupp to return, starting his 21-day practise window. He can be activated at any point over the next three weeks, or the team will be forced to shut him down for the remainder of the season.

Los Angeles coach Sean McVay, however, has hinted his return could be imminent.

If Kupp does suit up against 4-0 Philadelphia, it's uncertain if he'll be on a play count, as it would be his first game since Week 10 of the 2022 season after he missed the final eight contests with an ankle injury.

Kupp had 75 receptions for 812 yards and six TDs last year before getting hurt following a sensational 2021 season that saw him be named the Offensive Player of the Year.

Two seasons ago, Kupp led the NFL in receptions (145), receiving yards (1,947) and receiving touchdowns (16), then added six scores during the Rams’ playoff run that ended with a title and Kupp being named Super Bowl 56 MVP.

Although the Rams are missing one of the league's top receivers this season, Matthew Stafford has found a new favourite target to keep the offence rolling.

Rookie Puka Nacua leads the NFL with 39 receptions - the most by any receiver in league history through four games - while his 501 receiving yards trail only Minnesota Vikings receiver Justin Jefferson's 543 for the most in the NFL. Nacua's first career touchdown was a memorable one, as he scored on a 22-yard reception in overtime last Sunday to lead the Rams to a 29-23 win over the Indianapolis Colts to improve Los Angeles to 2-2.

Another relatively unknown receiver has also stepped up for the Rams, with Tutu Atwell catching 22 passes for 270 yards.

Seattle claimed their third-straight victory in dominant fashion as the Seahawks’ defence monstered the New York Giants en route to a 24-3 win.

The Seahawks sacked Giants quarterback Daniel Jones 10 times and came away with two interceptions, including a 97-yard pick six to rookie Devon Witherspoon.

The visitors opened the scoring at the end of the first quarter, Geno Smith finding DK Metcalf in the end zone on a six-yard reception.

New York were able to cut the gap through a 55-yard field goal from Graham Gano.

But the Giants’ offence was no match for Seattle’s defence and did not look like scoring again from there.

Seattle found the end zone again just before half-time and Witherspoon’s third-quarter score ultimately sealed the 21-point victory.

The Indianapolis Colts could be getting a big part of their offence back for Sunday's game against the visiting Tennessee Titans.

The Colts will activate Jonathan Taylor from the physically unable to perform list this week, and depending how he looks in practise, he could be on the field for their next game.

Indianapolis' first practise of the week is Wednesday, and it will mark Taylor's first of the season after he was placed on the PUP list at the start of training camp while recovering from ankle surgery.

Colts coach Shane Steichen told reporters on Monday that Taylor is excited to rejoin the Colts and get back to work.

The ankle injury wasn't the only issue this offseason for Taylor, as the 2021 NFL rushing champion had been mired in a contract dispute and had requested a trade.

Taylor, the runner-up for the NFL's Offensive Player of the Year in 2021, is entering the final season of his rookie deal and is scheduled to earn $4.3 million in 2023.

The fourth-year pro ran for a franchise-record 1,811 yards in 2021, but was slowed by injuries last year and was put on the PUP list earlier this summer as he recovered from ankle surgery that ended his 2022 campaign in December.

Ankle issues limited Taylor to 11 games last season, which he finished with 861 rushing yards and four touchdowns while averaging 4.5 yards per attempt.

Taylor averaged 5.5 yards per carry during his sensational 2021 season in which he also tied for the NFL lead with 20 total touchdowns while playing in all 17 games.

He'll be joining a 2-2 team that got No. 4 overall pick Anthony Richardson back in Sunday's 29-23 overtime loss to the Los Angeles Rams after the rookie quarterback suffered a concussion in Week 2. 

Without Taylor in the fold, Zack Moss has emerged as the team's No. 1 running back, and has rushed for 280 yards with a touchdown through three games.

Damar Hamlin said his return to the NFL “meant everything” nine months after suffering a cardiac arrest on the pitch.

The Buffalo Bills safety collapsed during a game in Cincinnati on January 2 and had to be resuscitated before being rushed to hospital.

Hamlin was cleared to resume his career and made his first NFL appearance on Sunday in the Bills’ 48-20 victory over the Miami Dolphins.

He told a post-match press conference: “That moment meant everything to me.

“I think it was more about proving something to myself than anything else, showing myself that I have the courage, I have the strength, I’ve got the pride, all those words, in me.

“To go through something so dramatic and be able to come back from it and to be able to still do what I love at the highest level in the world is amazing.”

Hamlin was the last player to emerge from the tunnel prior to the match and ran the length of the field before removing his helmet and soaking up the acclaim of the crowd.

Hamlin could be in the Bills’ side next Sunday when they travel to London to take on the Jacksonville Jaguars at the Tottenham Hotspur Stadium.

The Kansas City Chiefs held off a brave effort from the New York Jets to claim their third win of the season 23-20 on Sunday night.

Having lost Aaron Rodgers in game one and staring down a three-game losing streak, pressure was mounting on under-fire Jets quarterback Zach Wilson to stand up against the NFL’s heavyweights.

The 24-year-old was able to do just that despite the narrow defeat, throwing for 245 yards and two touchdowns without a turnover.

Chiefs quarterback Patrick Mahomes was below his best, giving up two intercepts with just one touchdown, but did just enough down the stretch to get Kansas City across the line with a late field goal.

Two of the NFL’s other best offences collided earlier on Sunday with the Buffalo Bills getting the better of the previously undefeated Miami Dolphins.

Bills quarterback Josh Allen was seemingly unstoppable, throwing for 320 yards and four touchdowns in a 48-20 win.

The Denver Broncos scraped past the Chicago Bears 31-28 to claim their first win of the season.

A 17-point fourth quarter lifted the Broncos to victory to leave the Bears winless through four games.

The early-season woes continued for the Cincinnati Bengals, who suffered their third loss of the season 27-3 to the Tennessee Titans.

There were also heavy losses for the Cleveland Browns and Pittsburgh Steelers, while the New England Patriots were steamrollered 38-3 by the Dallas Cowboys.

The Philadelphia Eagles stretched their winning streak to four with a 34-31 overtime win against the Washington Commanders.

Quarterback Jalen Hurts threw for 319 yards and two touchdowns, but it was Jake Elliott’s 54-yard field goal which ultimately got the Eagles over the line.

The Los Angeles Rams also had a narrow escape against the Indianapolis Colts, a touchdown to Puka Nacua in overtime ultimately proving the difference.

Elsewhere, the Los Angeles Chargers beat the Las Vegas Raiders, the unbeaten San Francisco 49ers downed the Arizona Cardinals 35-16, the Minnesota Vikings kept the Carolina Panthers winless with a 21-13 victory and the Tampa Bay Buccaneers cruised past the New Orleans Saints 26-9.