Hamza Rafia scored the winner on his debut as Juventus needed extra time to beat Genoa 3-2 and reach the quarter-finals of the Coppa Italia.

A much-changed Juve side were a cut above Serie A strugglers Genoa in the first half at Allianz Stadium on Wednesday, but made hard work of setting up a last-eight tie against Sassuolo or SPAL.

Dejan Kulusevski was outstanding in the opening 45 minutes, scoring inside two minutes and laying on a second goal for Alvaro Morata.

Lennart Czyborra pulled a goal back from out of the blue in an otherwise one-sided first half and Filippo Melegoni later equalised, but 21-year-old Tunisia international Rafia came off the bench to settle the tie late in the first half of extra time.

Romelu Lukaku hopes Inter are learning as they continue to struggle to perform consistently over 90 minutes despite sitting second in Serie A and reaching the quarter-finals of the Coppa Italia.

Lukaku headed an extra-time winner to see off Fiorentina 2-1 in the Coppa on Wednesday, his 119th-minute goal settling a tie in which Inter had led at half-time through Arturo Vidal's penalty.

A dominant first 45 minutes had seen the Nerazzurri attempt eight shots to Fiorentina's one, while having 56.6 per cent of the possession.

But Christian Kouame equalised after 57 minutes, prior to Lukaku's introduction as a substitute, as the Viola outshot their visitors nine to six in the second period.

For Inter, it was a second successive match in which they lost the initiative, even if Lukaku's goal this time meant they advanced to face Milan in the last eight.

At Roma on Sunday, despite trailing at half-time, quickfire goals from Milan Skriniar and Achraf Hakimi had Antonio Conte's men in front before they conceded a late leveller.

Ahead of the Roma game, Conte had bemoaned Inter's inability to make fast starts, having led at the interval just four times in Serie A this term.

But Lukaku is now concerned by his team's displays from half-time onwards, a period in which they have scored an impressive 30 goals and conceded just 12 in the league.

"I don't know why it happens," Lukaku told Rai Sport. "We already said it after the draw against Roma that it shouldn't happen, but it happened, even if we still won this time.

"We are young, we must learn from these things, but we want to improve."

Having booked the meeting with Milan, a fixture he was reluctant to immediately discuss, Lukaku acknowledged there were still positives.

"We are happy to have won a difficult match against a great coach [Fiorentina's Cesare Prandelli]," he said. "We are happy and we want to continue like this."

Turning focus back to Serie A, Inter face champions Juventus next on Sunday, with the Derby d'Italia rivals determined to win to keep the pressure on leaders Milan.

"I expect a tactical match between two teams who are doing good things," Lukaku added. "Juventus are a big team. We want to prepare well for this match."

Substitute Romelu Lukaku rescued Inter with a 119th-minute winner to knock Fiorentina out of the Coppa Italia with a 2-1 win for the second season running.

Lukaku started from the bench ahead of Sunday's Derby d'Italia against Juventus but was called for in the second half after Christian Kouame had cancelled out Arturo Vidal's penalty opener.

There was no immediate impact as the Nerazzurri sought to get their season back on track, having taken just a point from their prior two Serie A matches.

Yet Lukaku made his mark deep into extra time at the Artemio Franchi, powering a header past Pietro Terracciano to book Inter's place in the quarter-finals.

Stefano Pioli was glad to see Zlatan Ibrahimovic get another 45 minutes under his belt in Milan's penalty shoot-out win over Torino.

Ibrahimovic, 39, made his return from injury off the bench against the same opponent in Serie A on Saturday, but started and played 45 minutes three days later as Milan reached the Coppa Italia quarter-finals with a 5-4 penalty shoot-out victory.

Milan head coach Pioli was happy to see the forward, who has scored 10 goals in seven Serie A matches this season, get more game time after being out for seven weeks.

"We wanted to give him a longer time compared to the previous championship game. We preferred to let him play from the beginning due to his characteristics," he said, via Sky Sport.

"This time will be used to improve his condition in view of the next championship match."

The clash at San Siro finished 0-0 before Hakan Calhanoglu scored the decisive penalty in the shoot-out after Ciprian Tatarusanu had denied Tomas Rincon.

It meant Milan reached the Coppa Italia quarter-finals for the 12th consecutive season.

"I am lucky to have a team that knows how to fight, knows how to play, knows how to grit its teeth in a difficult match even for the qualities of our opponents," Pioli said.

"For the many occasions we had, we could have avoided even reaching penalties, but we went beyond physical and mental fatigue and this is a desired qualification."

Milan, who are three points clear atop the Serie A table, visit Cagliari on Monday.

Milan booked a place in the quarter-finals of the Coppa Italia with a penalty shoot-out victory over Torino at San Siro following a goalless draw after extra time.

The Serie A leaders eased to a 2-0 win when the sides met in the league on Saturday but found it a lot tougher to break down their opponents - 28 points worse off in the league - in Tuesday's cup tie.

Zlatan Ibrahimovic squandered the best early opening on his first start since November 22 and Milan then dominated the second half, twice hitting the post and having a penalty shout turned down.

Neither side could find a way through in the additional 30 minutes, but it was the hosts who prevailed on spot-kicks to set up a tie with Fiorentina or Inter - Hakan Calhanoglu scoring the decisive penalty after Ciprian Tatarusanu had denied Tomas Rincon.

Paulo Dybala could be out for almost three weeks after suffering a knee injury against Sassuolo on Sunday, Juventus have confirmed.

The Argentina international was replaced by Dejan Kulusevski in the 43rd minute of Juve's 3-1 Serie A win at the Allianz Stadium.

The club confirmed on Monday he has suffered a "low-grade lesion of the medial collateral ligament" in his left knee and will be out of action for "approximately 15-20 days".

The 27-year-old looks certain to miss the Coppa Italia clash with Genoa on Wednesday, the Supercoppa Italiana against Napoli next week and Serie A games versus Inter and Bologna. He could also miss another league game against Sampdoria on January 30.

Juve's only Serie A defeat this season came when Dybala was not in the side. Their win ratio without him is 40 per cent compared to 63.6 per when he features.

When going back to the start of the 2019-20 campaign, Juve have lost as many times in the 10 league games without Dybala (four) as they have in the 44 in which he has taken part – their win percentage sliding from 72.7 to 30 in his absence.

Juve also confirmed Weston McKennie and Federico Chiesa underwent tests on Monday, which revealed neither player is suffering from a serious injury.